PhD Student (gn*) Pediatric Hematology and Oncology

Jobbeschreibung

• You will conduct, analyze, and interpret the results e.g. of CRISPR technology and validation of experiments. You will be supported in analyzing data by bioinformatic pipelines, previously established in the Kerl group, and by collaborating partners.
• Part of Research Innovation

Qualifikation

• A master’s degree (or equivalent) in biology or a related field
• Practical experience in molecular biology techniques (e.g., RNA/DNA extraction, sequencing)
• Familiarity with bioinformatics tools and data analysis for single-cell RNA sequencing and epigenetics (or the willingness to learn)
• Strong analytical skills and the ability to work independently within a team
• A commitment to scientific rigor and enthusiasm for interdisciplinary research

Unternehmensbeschreibung

We are UKM. We have a clear social mission and, with our focus on healthcare, research and teaching, we bear a unique responsibility.
To meet our high standards every day, we are looking forward to your scientific expertise – ideally with you on board!
The Department of Pediatric Hematology and Oncology at the University Children's Hospital Münster is offering a PhD student position as part of an exciting project in the Kerl research group. The Kerl group investigates cellular heterogeneity and communication in pediatric tumors. We aim to explore the mechanisms driving cellular transformation in pediatric ependymomas, particularly how benign subependymomas transition to aggressive ependymomas.
The project "Epigenetic mechanisms in the physiological development and malignant transformation of primordial germ cells" is embedded in the DFG-funded Collaborative Research Centre 1748 'Principles of Reproduction'. The CRC 1748 involves scientists of the University of Münster, the University Hospital and Max Planck Institute Münster as well as the RWTH Aachen.
In this project, we will identify epigenetic modifiers in a single cell CRISPR screen that are relevant for physiological as well as SMARCB1-related pathological PGC development (transformation). Clinical impact of these epigenetic modifiers will be assessed by querying two clinically relevant cohorts.
The University Hospital of Münster is one of the leading hospitals in Germany. Such a position cannot be achieved by size and medical successes alone. The individual commitment counts above all. We need your commitment so that even with little things we can achieve great things for our patients. There are many possibilities open for you so that you may develop with them.

Benefits

• A highly motivated and communicative research environment within a successful translational working group
• A thorough introduction to the skills needed accompanied by supervision and guidance to develop oneself within a fascinating research field
• Access to advanced methodologies, including cutting-edge single-cell sequencing and spatial transcriptomics platforms
• Modern infrastructure and a state-of-the-art laboratory with committed colleagues to manage project-related challenges
• Support of new research ideas beyond the existing research program
• A unique opportunity to contribute to innovative research with clinical and translational implications
• Exciting Projects
• Professional Development and Training

Rechtliches

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Equal opportunities are a part of our Human Resources Policy. UKM supports the compatibility of work and family life and is certified as "Family-friendly Company" since 2010. Applications of women are specifically invited. In the case of similar qualifications, competence, and specific achievements, women will be considered on preferential terms within the framework of the legal possibilities. Handicapped candidates with equivalent qualifications will be given preference. Due to legal requirements working with us is only permitted with complete vaccination against measles.

Kontakt

For inquiries, please contact: Univ.-Prof. Dr. Kornelius Kerl or Maike Echtermeyer, T 0251 83-58078
Universitätsklinikum Münster
Albert-Schweitzer-Campus 1, Gebäude D5
48149 Münster
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